The heterotetradimers are formed subsequent the conversation of UPK2 and UPK3A moieties of the heterodimers. subsequent assembly within the endoplasmic reticulum and also the Golgi, six heterotetradimers arranged in inner and outer rings68 variety a 16?nm AUM particle or plaque (Fig. 3), packaged into DFVs and shipped to the apical membrane69. The